COURSE INTRODUCTION AND APPLICATION INFORMATION

Course Name
Molecular Basis of Gene Therapy
Code
Semester
Theory
(hour/week)
Application/Lab
(hour/week)
Local Credits
ECTS
BEN 513
Fall/Spring
3
0
3
7.5
Prerequisites
None
Course Language
English
Course Type
Elective
Course Level
Second Cycle
Mode of Delivery -
Teaching Methods and Techniques of the Course
Course Coordinator
Course Lecturer(s)
Assistant(s) -
Course Objectives The objective of this course is to introduce students molecular basis of cell gene therapy; viral and nonviral gene transfer techniques and gene therapy applications in hereditary and acquired diseases.
Learning Outcomes The students who succeeded in this course;
  • Describe the molecular basis of genetic diseases.
  • Compare the animal models used to model genetic diseases
  • Explain the therapeutic strategies in gene therapy.
  • Identify the viral and nonviral gene transfer techniques.
  • Discuss the ethics of gene therapy.
Course Description This course covers genetic diseases, gene therapy and molecular diagnostics.
Related Sustainable Development Goals

 



Course Category

 Core Courses
Major Area Courses
X
Supportive Courses
Media and Managment Skills Courses
Transferable Skill Courses

 

WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES

Week Subjects Required Materials
1 Cells and genomes An Introduction to Human Molecular Genetics (2nd Edition), J.J. Pasternak, 2005, Chapter 1
2 DNA Recombination and Repair An Introduction to Human Molecular Genetics (2nd Edition), J.J. Pasternak, 2005, Chapter 2
3 Viral Gene Delivery Systems An Introduction to Molecular Medicine and Gene Therapy, Chapter 4&5
4 Non-Viral Gene Delivery Systems An Introduction to Molecular Medicine and Gene Therapy, Chapter 4&5
5 Midterm 1
6 Animal models An Introduction to Molecular Medicine and Gene Therapy, Chapter 3
7 Immunotherapy in cancer An Introduction to Human Molecular Genetics (2nd Edition), J.J. Pasternak, 2005, Chapter 16
8 Muscle diseases An Introduction to Human Molecular Genetics (2nd Edition), J.J. Pasternak, 2005, Chapter 13
9 Metabolic diseases An Introduction to Human Molecular Genetics (2nd Edition), J.J. Pasternak, 2005, Chapter 12
10 Midterm 2
11 Gene therapy for infectious diseases An Introduction to Molecular Medicine and Gene Therapy, Chapter 11
12 Use of Stem cells in gene therapy An Introduction to Molecular Medicine and Gene Therapy, Chapter 2
13 Gene therapy clinical trials An Introduction to Molecular Medicine and Gene Therapy, Chapter 13
14 Ethics in gene therapy An Introduction to Molecular Medicine and Gene Therapy, Chapter 14
15 Review of the semester
16 Final Exam
Course Notes/Textbooks

An Introduction to Human Molecular Genetics (2nd Edition), J.J. Pasternak, 2005

An Introduction to Molecular Medicine and Gene Therapy 1st Edition by Thomas F. Kresina
Suggested Readings/Materials

Human Molecular Genetics (4th Edition), Tom Strachan & Andrew Read, 2010.

 

EVALUATION SYSTEM

Semester Activities Number Weigthing
Participation
Laboratory / Application
Field Work
Quizzes / Studio Critiques
2
10
Portfolio
Homework / Assignments
2
10
Presentation / Jury
1
15
Project
Seminar / Workshop
Oral Exam
Midterm
2
40
Final Exam
1
25
Total

Weighting of Semester Activities on the Final Grade
100
Weighting of End-of-Semester Activities on the Final Grade
-
Total

ECTS / WORKLOAD TABLE

Semester Activities Number Duration (Hours) Workload
Course Hours
(Including exam week: 16 x total hours)
16
3
48
Laboratory / Application Hours
(Including exam week: 16 x total hours)
16
Study Hours Out of Class
15
3
45
Field Work
Quizzes / Studio Critiques
2
4
Portfolio
Homework / Assignments
2
4
Presentation / Jury
1
6
Project
Seminar / Workshop
Oral Exam
Midterms
2
30
Final Exams
1
50
    Total
225

 

COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP

#
 Program Competencies/Outcomes
* Contribution Level
1
2
3
4
5
1

To be able to have adequate knowledge in Mathematics, Life Sciences and Bioengineering; to be able to use theoretical and applied information in these areas to model and solve Bioengineering problems.
2

To be able to use scientific methods to complete and apply information from uncertain, limited or incomplete data; to be able to combine and use information from related disciplines.

 X
3

To be able to design and apply theoretical, experimental and model-based research; to be able to solve complex problems in such processes.
4

Being able to utilize Natural Sciences and Bioengineering principles to design systems, devices and processes.

 X
5

To be able to follow and apply new developments and technologies in the field of Bioengineering.

 X
6

To be able to work effectively in multi-disciplinary teams within the discipline of Bioengineering; to be able to exhibit individual work.

 X
7

To be able to have the knowledge about the social, environmental, health, security and law implications of Bioengineering applications, to be able to have the knowledge to manage projects and business applications, and to be able to be aware of their limitations in professional life.

 X
8

To be able to have the social, scientific and ethical values ​​in the stages of collection, interpretation, dissemination and application of data related to the field of Bioengineering.
9

To be able to prepare an original thesis/term project in accordance with the criteria related to the field of Bioengineering. 
10

To be able to follow information about Bioengineering in a foreign language and to be able to participate in discussions in academic environments.

 X
11

To be able to improve the acquired knowledge, skills and qualifications for social and universal purposes regarding the studied area.
12

To be able to recognize regional and global issues/problems, and to be able to develop solutions based on research and scientific evidence related to Bioengineering.

 X

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest